Bridging Formulation and Analysis
Understanding how a drug substance is released from its dosage form is a critical component of early-stage development. At Scout Scientific, we provide dissolution testing specifically tailored to prototype scouting and formulation feasibility. By integrating dissolution studies with our high-precision HPLC analysis, we offer a streamlined workflow that helps our clients characterize product performance long before reaching formal clinical batches.
R&D Focused Dissolution Scouting
We specialize in phase-appropriate dissolution support. Rather than rigid, high-volume routine testing, we focus on the early-stage variables that define a product’s success. We assist formulation scientists in identifying the most promising candidates through comparative release profiles, providing the rapid, reliable data needed to make informed decisions on formulation direction and technical batch performance.
Specialized Dissolution Capabilities
- Media Scouting and Solubility: Evaluating various pH conditions and surfactants to achieve sink conditions for New Molecular Entities.
- Prototype Comparison: Comparative studies to help refine lead candidates and dosage forms.
- Method Verification: Developing and verifying dissolution methods to ensure they are discriminatory and robust for your specific technical batches.
- Formulation Troubleshooting: Identifying physical release issues like coning or tablet sticking early in the development cycle.
Hardware and Data Integrity
Our dissolution capabilities are anchored by the Distek 6100 system, a reliable and industry-proven platform for consistent sample agitation and temperature control. At Scout Scientific, the dissolution process and the HPLC analysis are part of the same high-integrity ecosystem. All samples generated from our Distek system are analyzed using Waters Empower 3, ensuring that the final release data is ALCOA+ compliant. This integration provides a single, traceable path from the dissolution vessel to the final chromatogram.
A Collaborative Scientific Approach
Analytical dissolution requires a combination of technical experience and a transparent, collaborative mindset. Our Principal Scientist manages the execution of every study, ensuring that standard protocols are followed while remaining attentive to the physical behavior of the dosage form during the run. For highly complex or non-standard challenges, we leverage our deep industry network and consult with specialized experts when necessary to ensure the most accurate interpretation and a successful path forward for your project.
